An Improved Canine Model of Subarachnoid Hemorrhage Using Intrathecal Indwelling Catheters.

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An improved canine model of subarachnoid hemorrhage using intrathecal indwelling catheters.

In the present study, the feasibility of intrathecal indwelling catheters in the preparation of a repeated subarachnoid hemorrhage (SAH) model in dogs, as well as chronic intrathecal administration of therapeutic agents against the ensuing cerebral vasospasm was examined. Briefly, through a small suboccipital incision, two catheters were introduced into the subarachnoid space so that their tips...

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Myosin light chain phosphorylation and contractile proteins in a canine two-hemorrhage model of subarachnoid hemorrhage.

BACKGROUND AND PURPOSE Subarachnoid hemorrhage (SAH) impairs both contraction and relaxation response in cerebral arteries. We tested the hypothesis that cerebral vasospasm might be ATP-independent contraction, such as latch state, and protein synthesis might be substantially downregulated due to ATP consumption after long-lasting contraction. METHODS Chronic cerebral vasospasm was induced in...

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ژورنال

عنوان ژورنال: Journal of Veterinary Medical Science

سال: 1997

ISSN: 0916-7250,1347-7439

DOI: 10.1292/jvms.59.825